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Although both substances show nerve-damaging properties in cell experiments, it is still uncertain how much these come into effect in biological concentrations

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The researchers noted that serious problems resulting in hospitalization were more common among elderly patients taking this combination

They exhibited increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy