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In our study, we did not observe an increase in loose stools in NAC-treated animals during daily monitoring, consistent with previous research showing no toxicity after 30 days of high-dose NAC (1200 mg/kg/day) in rats [109]

Bioinspiration in nanomedicines has revolutionized targeted drug delivery by drawing inspiration from natures precision targeting mechanisms

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Methods In vitro experiments Biochemical binding assay Biochemical binding of TLC-2716 and TLC-6665 to LXR or LXR was determined by time-resolved fluorescence resonance energy transfer-based biochemical assays evaluating the concentration-dependent displacement of a N-terminally biotinylated coactivator NCOA3 to recombinant glutathione S -transferase (GST)-tagged LXR or LXR ligand-binding domain (LBD)

The Warburg effect reinterpreted 100 yr on: a first-principles stoichiometric analysis and interpretation from the perspective of ATP metabolism in cancer cells