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To address this, researchers have developed strategies such as local administration, targeting ligands on CPPs, or using activatable CPPs that penetrate only under specific biological stimuli

Book Chapters Fagan JJ, Zafereo ME , Marcus K, Russell MD, Randolph G

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Interestingly, although MHI-148 has been reported to permeate the BBB in intracranial GBM models, near-infrared images of a healthy mouse brain 4 hours after retro-orbital injection of MHI-148 showed no significant fluorescence, reinforcing the tumor-specificity of HMCDs