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Thus, genetically determined increased TLR2 level (rs1816702), MD-2 level (rs11465996), TNFRSF1A (TNFR1) expression (rs4149570) and genetically determined decreased IL-1 (rs3804099), IL-6 (rs3804099) and IFN- (rs2430561) levels were associated with beneficial response among patients with CD