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While metabolic reprogramming towards increased glycolytic flux to favor increased cell proliferation is a recognized hallmark of cancer, functional mitochondria remain essential in maintaining malignant cell bioenergetics in particular tumors, including those of lung and brain [45-47]

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Front Neurosci 9:403 Le Poul E, Bola C, Girard F, Poli S, Charvin D, Campo B, Bortoli J, Bessif A, Luo B, Koser AJ, Hodge LM, Smith KM, DiLella AG, Liverton N, Hess F, Browne SE, Reynolds IJ (2012) A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinsons disease