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Together with the kinetic model, an approximated form of expression derived for the dose-response clarifies the role played by the individual biochemical processes and allows us to identify three distinct regimes for the downregulation that emerge from the balance between phosphorylation, dephosphorylation and the cellular level of -arrestin

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Vitiligo is more severe in patients with darker skin Le Poole, who has spent more than 30 years studying vitiligo, said the disease has been found to be more severe in people with darker skin tones

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