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The combination of NNC with D-threo-PPMP (PPMP), a UDP-glucose ceramide glucosyltransferase(UGCG) inhibitor, further improved the antitumor activity of MAPKi in melanoma models [61]

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Palmitoylethanolamide (PEA), a lipid-derived peroxisome proliferator-activated receptor- (PPAR-), is shown to dismantle lipid droplets via -oxidation and restore innate cellular defenses 711

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Cyn emerges as a promising candidate, as it not only polarizes microglia from a pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotypea key switch for resolving neuroinflammationbut also reverses ferroptosis markers such as GSH, GPX4, and MDA