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The spatial and functional overlap between reduced m6A marks and impaired TDP-43-RNA interactions suggests a synergistic mechanism: the loss of METTL3-mediated m6A modification may destabilize RNA-protein complexes, exacerbating the inability of TDP-43 to regulate splicing fidelity (Tollervey et al., 2011)

Characterization of a processing protease that converts the precursor form of gamma-glutamyltranspeptidase to its subunits

Bass C, Puinean AM, Andrews M, Cutler P, Daniels M, Elias J

The prevalence of vitamin D deficiency is known to occur in individuals with autoimmune disease, and more than half of North Americans dont get enough vitamin D

The C 1 carbon is modified by the addition of polar head groups (relatively more hydrophilic residues)