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Based on Glide score (GScore), an empirical scoring function that approximates the ligand binding free energy, 3-carene (GScore: -5.39 kcal/mol) has lower binding energy and affinity than -pinene (GScore: -6.57 kcal/mol), zolpidem (GScore: -9.22 kcal/mol), and flumazenil (GScore: -8.78 kcal/mol) [33, 34]