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doi: 10.1016/j.jnutbio.2021.108840 207 MohagheghNIyerAWangEBalajamNZKangHAkbariMet al

PMC 5431260

This suggests that PDA@Pt + Laser exerts excellent therapeutic efficacy on acute gout in rats by inhibiting the NF-B signaling pathway and downregulating inflammatory factor expression (Figure S15)

Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

It also supports antioxidant and cellular detoxification pathways in the body