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Since then, a considerable amount of NK research has been performed on NK in Japan, Korea, China, and the United States, and these studies confirmed that NK, an alkaline protease of 275 amino acid residues with a molecular weight of approximately 28 kDa, 4 is the most active ingredient of natto and is responsible for many favourable effects on cardiovascular health

They communicate with cells and help direct biological processes such as immune function, energy production, and in relation to skin health specifically, tissue repair

These overlapping functions include facilitation of LTP and calcium signaling, memory enhancement, vascular angiogenesis, facilitation of blood flow and cerebroprotection, augmentation of dendritic arborization and synaptogenesis, and neurogenesis [48]

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