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Various topical, oral, and injection-based cosmetic skin-lightening agents with different mechanisms of action are used widely across Asia, including hydroquinone, azelaic acid, kojic acid, mulberry, alpha-arbutin, beta-arbutin, glutathione, licorice root, papaya, vitamin A (e.g., retinol), vitamin B (i.e., niacinamide), and vitamin C

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A meta-analysis of randomized controlled trials found they can improve tendon structure, strength, and post-exercise recovery when combined with resistance training, though the quality of evidence remains moderate. Innovation is exciting, but recommending injectable, unregulated peptides to patients, without clinical validation should give us pause

In addition, FMT therapy can also significantly improve intestinal leakage, liver damage and inflammation caused by alcohol (Lamas-Paz et al., 2024)

Recently, several investigators, including us, have evaluated the effects of intra-arterial infusion of NO agonists, such as acetylcholine, methacholine and bradykinin, and intra-arterial infusion of NO antagonists on forearm blood flow using a mercury-filled Silastic strain-gauge plethysmography and the effects on coronary blood flow using a Doppler flow guide wire