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The l-EVs were prepared from culture media of HEK293 cells expressing Halo7-MIM I-BAR and labeled with SaraFluor 650T-conjugated Halo ligand as described above

Similarly, a Phase II clinical trial assessing PX-12 in patients with previously treated advanced pancreatic cancer was terminated due to a lack of notable clinical efficacy [230]

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NMN (nicotinamide mononucleotide): A systematic review of randomized controlled trials found human NMN doses ranged from 150 to 1,200 mg per day, with no major adverse effects reported