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The elevated calcium levels also impair mitochondrial function, triggering the release of proapoptotic factors, including cytochrome c, and activating caspase-dependent apoptotic pathways ( tThe excitotoxicity induced by METH also triggers neuroinflammation and amplifies its neurotoxic effects

They become invasive after detaching from the primary tumor, because they acquire ability to penetrate to the bloodstream or the lymphatic system, to grow and thrive in their new location, and to induce angiogenesis