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doi: 10.1016/j.cell.2011.09.024 120 AzevedoASFollainGPatthabhiramanSHarleppSGoetzJG

Deleted mtDNA in patients cells exists in varying proportions relative to normal mtDNA, a mixture termed heteroplasmy

Although the auto-amplifying mechanism between inflammation and cell death in MS pathology is generally recognized, no cell death-targeting therapies have made it to the clinic yet