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Excess copper promotes glutathione (GSH) oxidation, leading to catecholamine oxidation (39)

Elevated Mt1/2 levels in Atp7b / :Prnp / animals should facilitate better Cu sequestration and detoxification, as reported in other Atp7b-deficient mouse strains 49

60 Liraglutide was subsequently approved for marketing in February 2010, 62 and lixisenatide was approved for marketing in the European Union in 2013 for the treatment of T2DM and in the United States in July 2016