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We assessed six rodent models of ASD as part of this translational study, and showed that the abnormality seen in individuals with ASDnamely a striatal glutamate deficitwas recapitulated in VPA-exposed mice, Nlgn3 R451C KI mice, and Nlgn3 KO rats

Additionally, we discovered that the presence of PI3K inhibitor significantly diminished the suppressive effect of SLC38A5 on MDA and ROS levels (Fig

M., Oh B., et al

The authors concluded that 1-year treatment outcomes for TNF inhibitor monotherapy and csDMARD co-therapy were very similar, although certain subgroups of patients (for example, those with peripheral arthritis) might benefit from co-therapy 96