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A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance

Methods: We included patients aged 18-49 years with a first-ever CIS, along with sex- and age-matched stroke-free controls from 19 European centers

Given that the pathogenesis of antiretroviral toxic neuropathy is based on the disruption of mitochondrial energy supply one can assume that the clinical effect of ALCAR is dependent on its mitochondrial availability