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These three enzymes work together and convert MG into D-pyruvate which enters into TCA cycle and thus the toxic metabolite MG is used for energy production

The four-leaf model includes a fourth gene, GSTA2 , and results in a combined risk set with an OR = 5.79

Cell Host Microbe 18 , 3848 (2015)

Juarez, D

Figure 3 The incidence of acute respiratory distress syndrome when stratified by history of alcohol abuse There are likely many potential mechanisms by which alcohol abuse increased susceptibility to developing ARDS (Figure 4)