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83 The TR/Trx system appears to be connected to the GR/GSH system

A slightly increased concentration of hydrogen peroxide leads to the activation of several key signaling pathways, such as the NF-kappaB pathway (Valko et al

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External cholesterol can directly activate the oncogenic Hedgehog pathway, and internal cholesterol can induce mTORC1 signaling ( 2.4 Effects of metabolism on immune cells in the TME Tumor-infiltrating immune cells have dual characteristics, some of which have the function of inhibiting tumor proliferation and metastasis, such as CD8+ cytotoxic T cells, natural killer (NK) cells, M1 macrophages, dendritic cells (DCs), etc., while others may be beneficial to tumor development, including Treg cells, M2 macrophages ( The proliferation of tumor cells and immune cells depends on glycolysis, and tumor cells compete for glucose, which makes immune cells lack nutrients and unable to perform their functions ( When glucose availability is limited within the TME, tumor-infiltrating immune cells may undergo metabolic reprogramming to sustain their functional capacity, notably by increasing the uptake and oxidation of fatty acids (FA)

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