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10.3389/fnut.2020.00091 232

Hongliang Y, Xudong Y, Xian X, Meiqian X, Yanlei Y, Chunling X et al

cDNA expression was induced with 1 g/mL of doxycycline (sigma-Aldrich, D3447) for 12-24 h before assays were conducted

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Elevated insulin causes an increase of free serum IGF-1, nevertheless, as resistance to insulin progresses, the liver becomes insensitive to insulin-mediated suppression of IGFBP-1 [254, 256]