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cation 2k may be prepared from quinoline-N-oxide 14 or the like, which may be derived from quinoline via a mCPBA oxidation (Scheme 4)

These causes can also be categorized into reversible and irreversible, indicating the potential for recovery or the permanence of the condition, respectively

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This is part of why B12 has a strong safety record, and it is also why levels sometimes need regular replenishment during active treatment