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223 , 224 , 225 , 226 In conclusion, the gut-brain axis plays an important role in the pathogenesis of PD, and in-depth study of the relevant mechanisms of the gut-brain axis will not only help us better understand the pathogenesis of PD but also may provide a theoretical basis for the development of new treatment strategies

Harvard Magazine

In this review, we explore the complex interplay between sleep, metabolism, and aging across five core themes: (1) the role of sleep in maintaining optimal free radical levels, (2) whether ROS directly contribute to or mediate sleep disturbances in aging, (3) how age-related sleep disturbances may, in turn, contribute to impaired brain metabolism and exacerbate age-related changes, (4) the role of sleep, redox, and aging in peripheral systems, and (5) the evidence that improving mitochondrial redox potential restores sleep and slows aging, as well as the potential benefits of interventions like exercise, antioxidant-rich foods, supplements, and specialized diets that enhance sleep and/or metabolic efficiency, and their effects on aging markers (summarized in Figure 1)

Two variants occurred in target region 4, intronic to MGMT

Mild digestive issues with NMN NMN works well for most people, but some users face mild side effects at the time they start taking it