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According to the World Health Organization, more than 55 million people are affected with dementia, and nearly 10 million new cases are diagnosed each year

As reviewed by Amersfoort et al., the tissue-specific nature of ECs is critical for accurately recapitulating organ physiology and immune interactions (197, 198)

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In patients with T2DM, lo ng-term hyperglycemia and hyperlipidemia mainly alter the diversity and composition of the GM through several mechanisms: (i) persistent hyperglycemia changes the intestinal metabolic microenvironment, remodels the microbial community structure, promotes sugar-loving bacteria, and inhibits anaerobic bacteria (46)

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