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The combination of N-terminal amine, histidine at position 2, and intervening amide nitrogen is a recurrent high-affinity copper-binding motif in peptide biochemistry the same general motif also appears in human serum albumin's N-terminal copper-binding site

Five to ten minutes

Lipid-polyethylene glycol-coated iron oxide nanoparticles that continuously released doxorubicin and could raise the temperature to 43 C under magnetic field intervention to produce sufficient heat, achieving effective combination of chemotherapy and hyperthermia [81]