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Vitamin B12 can interact with medications such as colchicine (a medicine used to treat gout), metformin (an anti-diabetic agent), excessive alcohol, vitamin C products, extended release potassium products, antibiotics such as gentamicin, neomycin, tobramycin, anti-seizure medications such as phenobarbital, phenytoin, primidone, medicines used to treat heartburn like H2 blockers such as cimetidine and proton pump inhibitors such as omeprazole, antacids such as ranitidine, cimetidine

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Echinocandins inhibit the fungal (1,3)--D-glucan cell wall biosynthesis and low toxicity, serving as the first-line drugs for invasive infections in critically ill patients (Pappas et al., 2016)

However, a key counterargument challenges a direct causative role