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Both Crohns disease and colitis severely affect gut health and can prevent sufficient B12 absorption (Sobczyska-Malefora et al., 2021)

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doi: 10.1016/j.ejim.2014.09.007 18

The warning signs of a vitamin B12 deficiency A pale yellow tinge to your skin A sore and red tongue (glossitis) Mouth ulcers Pins and needles (paraesthesia) Changes in the way that you walk and move around Disturbed vision Irritability Depression Changes in the way you think, feel and behave A decline in your mental abilities, such as memory, understanding and judgement (dementia)

There is no established safety data for the combination in any population, so the honest position is that contraindication data does not exist at the combination level