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Vitamin B12 is the essential cofactor that lets the Folate Cycle hand a methyl group to homocysteine (via methionine synthase), enabling methionine SAMe production; SAMe is the cell's universal methyl donor Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication PMC AMINO ACID METABOLISM : METHIONINE DEGRADATION New Insights into the Roles of Cysteine and Homocysteine in Pathological Processes IntechOpen Frontiers Redox metabolism in cell senescence: focusing on contributions from the metabolomic field
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