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Bescherming van de lever De hepatoprotectieveBeschermend voor de lever, het vermogen om levercellen te beschermen tegen schade

152 Dysregulation of Wnt/-catenin signalling is often caused by mutations of various components in the pathway, particularly mutations or silencing of the Wnt tumour suppressor, which occurs frequently in various cancer types, such as adenomatous polyposis coli (APC) mutations, 193 Axin1/2 mutations, 194,195 GSK3 deletions, 196 inactivation mutations of E3 ubiquitin ligase RNF43, 196 and Znrf3

Astrocytes generate an inductive tightening influence on the endothelium through the production of sonic hedgehog (Shh) (Alvarez et al., 2011) and basic fibroblast growth factor (bFGF) (Sobue et al., 1999) that assist in forming a restrictive BBB by promoting endothelial expression of tight junction (TJ) proteins, occludin, claudins, and zonula occludens (ZO)