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Updating these calculation inputs at regular reconciliation intervals will result in a rebate amount that more fully reflects the majority of shifts in the underlying data following additional time for claims run-out, which refers to the maturation of PDE records in CMS' internal PDE database

PMID: 33414489

This translational gap motivates an engineering solution: polysaccharide-based nanomedicines that exploit the inflammatory microenvironment (pH, ROS, bacterial glycosidases, receptor overexpression) to achieve spatiotemporally controlled delivery and thereby amplify the very mechanisms delineated above

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