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However, as an avascular tissue, the intrinsic microenvironment of the intervertebral disc is characterized by extreme features such as hypoxia, low nutrient levels, high acidity, hyperosmolarity, and sustained mechanical stress (Zhang et al., 2022)

Toll-like receptor 4 deficiency reduces oxidative stress and macrophage mediated inflammation in hypertensive kidney

J Neurochem 50:929935 Mamczur P, Borsuk B, Paszko J, Sas Z, Mozrzymas J, Winiewski JR, Gizak A, Rakus D (2015) Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes

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