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Neither route has been directly compared for safety in clinical trials

doi: 10.1016/j.ijrobp.2020.12.019 356 LiangSHuDLiGGaoDLiFZhengHet al

A defining feature across the patients was a twophase dosing strategy: an initial loading phase (high dose/frequency until symptom resolution) followed by a maintenance phase (lower dose/frequency lifelong)

This systematic study showed that phytochemicals inhibit the release or activity of mast cells, such as histamine, inhibit the secretion of Th2 cytokines, such as IL-4, IL-5, IL-13, and GATA-3, and reduce IgE levels as well as macrophages and lymphocytes