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An important feature of astrocytic interaction with the BBB are the perivascular end feet which closely interact with the vascular walls and almost completely cover the entire cerebral vasculature [48]

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates

These two protein families have high specificity and affinity to their targets, as well as high resistance to proteases

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