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Another possibility leading to the decrease in glucose is a key enzymes activity decrease in the TCA, with both pyruvate dehydrogenase complex, which provides acetyl-CoA, and alpha-ketoglutarate dehydrogenase complex (KGDHC) decreasing in AD (Bubber et al., 2005)

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Although many studies reported promising results with minimal toxicity or side effects, there were study limitations such as small sample sizes, variability in formulations, and the pharmacokinetic properties of curcumin

Frontiers in Endocrinology , 7 , 30 Merrick, D., Sakers, A., Irgebay, Z., Okada, C., Calvert, C., Morley, M