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Description

Calcedo R, Vandenberghe LH, Gao G, Lin J, Wilson JM

NQO-1 prevents redox cycling of quinones, thereby reducing ROS production

doi: 10.1016/j.metabol.2020.154455

Once taken up by neurons, L-lactate is converted back to pyruvate to support the Tricarboxylic Acid (TCA) cycle ( 6.3 NADPH oxidase activation and oxidative burst Memory loss is a key characteristic of Alzheimer's disease (AD), a neurodegenerative condition caused by a complex pathological process that involves the overproduction of reactive oxygen species (ROS) (104)