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[15] [13] Other notable adverse effects include: Hypoglycemia : Low risk when used as monotherapy, but increased when combined with insulin or sulfonylureas Injection site reactions : Erythema, pruritus, or discomfort in approximately 2% to 4% of patients Fatigue and dizziness : Reported in 5% to 8% of participants Increased heart rate : Mean increases of 2 to 4 beats per minute observed [1] [2] Serious adverse events were uncommon but included acute pancreatitis (approximately 0.2% incidence), gallbladder disease including cholecystitis and cholelithiasis (0.6% in diabetes trials and up to 2.5% in weight management trials, associated with rapid weight loss), and acute kidney injury, typically in the context of severe dehydration from gastrointestinal symptoms

Bruun JM et al

In chloroplast, MDHA is reduced to AsA by photoreduced ferredoxin at a high rate and this is likely to constitute the main pathway of AsA regeneration in the vicinity of the thylakoid membrane

By promoting angiogenesis, BPC-157 may address one of the fundamental limitations in soft tissue repair