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10.1016/j.tibs.2015.11.012 11 BrownC

Buildup of any of the substrates within the cycle can and does lead to negative feedback

In some embodiments, preparation of certain cations of Formulas I and IA may occur by alkylating the N-positions of the quinoline scaffold using, for example, iodomethane or methyl trifluoromethanesulfonate (see Scheme 1)