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Cystathionine gamma-lyase deficiency mediates neurodegeneration in Huntington's disease

Eckstein JA, Ammerman GM, Reveles JM, Ackermann BL

It is a specifically potent JAK3 and TYK2 inhibitor (EC50 less than 5 nM) 75 and thus can effectively block IL-2, IL-4, IL-6, and IL-7

Further studies on free-radical pathology in the major central nervous system disorders: effect of very high doses of methylprednisolone on the functional outcome, morphology, and chemistry of experimental spinal cord impact injury