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Suppression of high glucose-induced cell proliferation in HepG2 cell line model by lutein was linked to increased expression of high glucose-mediated repressed HO-1 and prevention of hyperglycemia-mediated elevated ROS, but it was not associated with the induction of apoptosis

When administering a higher dose, the benefits should be weighed against the risks

Major components involved in the CIA system are shown in Table 2

Statistical analysis Statistical analyses were performed with two-tailed Students t test, one-way ANOVA or two-way ANOVA followed by Tukeys or Bonferronis post-hoc test, or analysis of covariance (ANCOVA) using GraphPad Prism software (version 10)

doi: 10.1016/j.redox.2020.101650 24 ZhangYMurugesanPHuangKCaiH