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Glutathione synthetase deficiency is an exceptionally rare autosomal recessive metabolic disorder (33

The same time interval results in 100% mortality of infected mice in the placebo group

Given that features of ACLF and extrahepatic manifestations of ALD were common, these findings suggest that severe AAH should be classified as ACLF, which carries a high short-term mortality, portends a poor prognosis, and urgently warrants further study

6 Future directions and perspectives There is growing consensus that the aberrant activation or suppression of ferroptosis is crucial to the pathological progression of numerous liver diseases, making it a promising therapeutic target for the treatment of hepatic disorders