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In hypercholesterolemic mice, deletion of Arg2 or inhibition of arginase with BEC improves endothelial function and reduces atherosclerosis (Ryoo et al., 2008)

AsALG-6 is eliminated during Ascaris programmed DNA elimination 65,66,67

Furthermore, our previous omics analysis of fibroblasts isolated from a MSS patient identified an upregulation of CAT and both the isoforms of SOD (Cu-ZnSOD, MnSOD) 26,30

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DBCO-chloroalkane anchoring within HaloTag To mitigate the potential impact of a longer chloroalkane linker, we employed an azide tag that could then undergo an in cyto SPAAC reaction 30,31 with DBCO