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Another aspect of GST catalysis by necessity involves transfer of a negative charge en route to, and as part of, the transition state (as the nucleophilic GSH thiolate attacks the electrophilic substrate)

We've already noted that glutathione is made up of three amino acids: cysteine, glutamic acid, and glycine

The reduced form of L-glutathione is an antioxidant that protects cells and tissues by scavenging free radicals

Received: 27/05/2017 Introduction Multidrug resistance (MDR) is a unique type of resistance by which cancer cells develop cross resistance to a broad spectrum of anticancer agents [1]