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Pritchard J, Han R, Horst N, Cruikshank WW, Smith TJ

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10.1016/j.jcyt.2017.03.073 55 QiL.ZushinP.-J

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Indeed, men display reduced levels of HDL-C and a more pro-atherogenic phenotype compared to women ( Furthermore, estrogens are well-recognized EC protective molecules, able to stimulate NO production, EC growth and wound healing mechanisms ( In this Review, we mainly focused on the influence of sex-specific factors on both HDL and EC function and how sex-dependent differences modulating HDL-EC cross- talk may contribute to the CV protection of pre-menopausal women compared to age-matched men ( HDL-targeting drugs: The failure of cholesteryl ester transfer protein inhibitors The concept that HDL is the good cholesterol first originated from the Framingham Heart Study, which showed strong inverse association between HDL-C and coronary heart disease (CHD) ( In line with the notion that HDL-C alone may not be a reliable marker of the cardio-protective quality of HDLs, it has been recently shown in a sex-mixed pool of patients that CETP inhibitors, Torcetrapib and Evacetrapib, not only increased HDL-C but also enhanced the concomitant content of apoC3/apoE in HDLs