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The association of baseline antibodies (8587, 109, 110), baseline cytokine levels (65, 66, 111, 112), and immune cell changes (79, 83, 113116) suggests that humoral and cellular immunity play a role in some specific irAEs

The circadian clock is a system regulating behavior and function of the human body, thus playing a crucial role in health maintenance

Siegel RL, Miller KD, Fuchs HE, et al

For Saci_2033 the assay was conducted in 0.1 M MOPS-KOH buffer (pH 6.5 at 50 C), 5 mM MgCl 2 , 5 mM ATP, 0.2 mM NADH, 2 mM PEP, 14 U LDH, 7 U PK using 0.25 g of purified Saci_2033