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Mientras el perfil neurotxico de los agentes quimioterpicos anteriores est claramente establecido, con otros frmacos como lenalidomida, anlogo estructural de la talidomida, ste es ms controvertido59

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Experimental work examines how hCG and hyperglycosylated HCG may actively promote malignant invasion, angiogenesis, and immune evasion in trophoblastic cancers

In a hyperglycemic state, the affinity of aldose reductase for glucose rises, causing much sorbitol to accumulate, and using much more NADPH, leaving less NADPH for other processes of cellular metabolism

The problems arise when it comes to accounting for this behaviour within a reductionist paradigm of conventional biochemistry