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Tirzepatide is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg for 4 weeks (a non-therapeutic initiation dose to improve tolerability), then increased every 4 weeks to reach a therapeutic dose of 5-15 mg weekly based on response and tolerability

The combination works by addressing underlying healing deficits rather than just masking symptoms

The retinoid comparison makes GHK-Cu discontinuation appear favorable since copper peptide cessation typically produces gradual benefit decline without rebound worsening or dramatic rapid reversal

doi: 10.1113/jphysiol.2012.232975, 73 NitscheM

Details of this review can be found in previous publications,101112 and supplementary table 5 provides comparisons of the population, intervention, comparison, outcome, and study type for each review