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Reported Mild Effects: Temporary injection site redness Slight drowsiness (when dosed in evening) Vivid dreams or altered sleep patterns Mild headaches during initial days Management Strategies: Rotate injection sites regularly Reduce dosage if effects seem excessive Maintain hydration throughout protocol Consider timing adjustments for sleep-related effects When to Modify or Discontinue Certain situations warrant protocol modifications or discontinuation

In severe cases, it can lead to neurological changes and anemia

the proportion of patients who experienced at least one MACE was 3.8% with semaglutide oral tablets and 4.8% with placebo