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Participants were randomly assigned to receive intramuscular, or into-the-muscle, injections of one of two doses of methylcobalamin (25 or 50 mg), or a placebo, twice a week for 3.5 years

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Oral supplements exhibit less than 15% bioavailability due to gastrointestinal absorption limitations

High B12 Levels Can Still Be A Sign Of Something Else That said, a persistently high B12 level on a blood test is worth paying attention to not because the B12 itself is dangerous, but because it can be an indicator that something else is going on in the body