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Under conditions such as chronic inflammation or specific tissue microenvironments, NRF2 activation may promote ferroptosis by upregulating genes involved in iron metabolism and lipid peroxidation, particularly when antioxidant defenses are overwhelmed

Liu XG, Huang DL, Lai C et al (2019) Peroxidase-like activity of smart nanomaterials and their advanced application in colorimetric glucose biosensors

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Key Summary Yes, Vitamin C plays an important role in helping the body maintain and recycle glutathione

Xing, X., Dan, Y., Xu, Z