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Copper is related to the normal function of sperm, whereas manganese affects sperm motility and fertilization (138)

NADP-dependent isocitrate dehydrogenase is inactivated by glutathionylation of a specific residue of cysteine by glutathione disulfide, which binds to a regulatory cysteine residue by trans-sulfuration

Nakamura T, Hipp C, Santos Dias Mouro A, Borggrfe J, Aldrovandi M, Henkelmann B, et al

With regard to distribution , for drugs such as diazepam 1 and penfluridol 5 that are substantially distributed into adipose tissue, greater adiposity is associated with greater storage of the drug in lipid reservoirs, and hence greater availability of the drug for return to blood as blood levels fall due to metabolism